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Dean L, McEntyre J. The Genetic Landscape of Diabetes [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004.

The Genetic Landscape of Diabetes [Internet].

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Dean L, McEntyre J.

Table 1Comparison of Type 1 and Type 2 Diabetes

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Type 1 diabetesType 2 diabetes
PhenotypeOnset primarily in childhood and adolescenceOnset predominantly after 40 years of age*
Often thin or normal weightOften obese
Prone to ketoacidosisNo ketoacidosis
Insulin administration required for survivalInsulin administration not required for survival
Pancreas is damaged by an autoimmune attackPancreas is not damaged by an autoimmune attack
Absolute insulin deficiencyRelative insulin deficiency and/or insulin resistance
Treatment: insulin injections Treatment: (1) healthy diet and increased exercise; (2) hypoglycemic tablets; (3) insulin injections
GenotypeIncreased prevalence in relativesIncreased prevalence in relatives
Identical twin studies: <50% concordanceIdentical twin studies: usually above 70% concordance
HLA association: YesHLA association: No

* Type 2 diabetes is increasingly diagnosed in younger patients.

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